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Wiley, New York Yu J, Zhou C (2007) Crystal structure of glutathione reductase Glr1 from the yeast Saccharomyces cerevisiae

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The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at C-3 position by polar functional groups caused dramatic decline in its potency and efficacy 38

10.1016/j.ejpb.2009.01.005 180 PaliwalR.PaliwalS