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Eli Lilly announced positive Phase 3 results for retatrutide, a first-in-class triple agonist targeting GLP-1, GIP, and glucagon receptors

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In this phase 2 trial in participants with obesity and MASLD, once-weekly treatment with the GIP/GLP-1/GCG triple agonist retatrutide resulted in substantial reductions in liver fat, body weight, ASAT and VAT, which were associated with improvements in insulin sensitivity, serum lipids, K-18 and pro-C3