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If you are following a semaglutide dosage chart and your protocol spans several weeks, this 28-day window after first use becomes the practical limiting factor

[1] [2] According to the FDA prescribing information for Zepbound, in clinical trials, nausea occurred in approximately 24-29% of patients taking Zepbound (compared to 9% on placebo), while vomiting affected roughly 6-12% of users (versus 2% on placebo)

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These are gastrointestinal effects caused by delayed gastric emptying

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Its ability to reduce IL-6, TNF-alpha, and NF-kB activation addresses the core inflammatory drivers of psoriatic plaques