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It may be important to include measurements of biomarkers of oxidative damage (e.g., products of DNA and lipid oxidation, such as 8-hydroxy-2-deoxyguanosine, 8-OHdG, or F 2 -isoprostanes) in observational studies, suggesting that the therapeutic benefit may actually be associated with an antioxidant effect (Moosmann and Behl, 2002

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Key susceptibility genes are involved in pathways such as mucin production, surfactant metabolism, telomere maintenance, immune regulation, and epithelial integrity [20]