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Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism

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Furthermore, failure to ensure all data is retained and timely transferred to the archives can result in incomplete documentation of the study in the archives and could limit reconstruction and evaluation of the study

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