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The Promise of GLP-1 Drugs: More Than Just Diabetes Management When GLP-1 (Glucagon-Like Peptide-1) receptor agonists first hit the market, they were hailed as a breakthrough in type 2 diabetes

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While the difference was not dramatic (~3 points, which is well below the minimally clinically important difference in the MDS-UPDRS-3 of around ~5 points), it appeared to remain after a 2-month washout period, intended to support the idea that, because the improvements remained after removal of the incretin, the difference should be a disease-modifying, rather than a symptomatic benefit