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Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates

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To make the hEC surface charge more positive the glycocalyx of hECs was digested with neuraminidase enzyme (1 U/ml, 1-h pretreatment) or cultures were treated with cationic lipid 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH

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Luzindole (30mg/kg

The timing remains similar to injection protocols (1-3 hours before activity) with possibly 30-45 minute faster onset due to direct mucosal absorption