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no skin discoloration occurs at therapeutic levels

As summarized in Table 1, key genes involved in bile acid metabolismsuch as FXR, SHP, and ASBTare regulated by specific microbial population like Firmicutes, Lactobacillus , and Bacteroides , influencing bile acid reabsorption and enterohepatic circulation

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Prevents oxidative stress

Milk thistle is an ingredient that has been shown to improve liver health (11) and may also help increase glutathione (12) levels

This legal gray area continues evolving as clinical evidence accumulates