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PMID 18273687

Discontinuous gradient method: Dilute OptiPrep with 0.25 M sucrose, 6 mM EDTA, 60 mM Tris-HCl, pH 7.4 to produce 14%, 25% and 55% (w/v) iodixanol

The onset of a Herxheimer reaction is somewhat diagnostic of a spirochetal infection

In particular, we hereby propose the putative functionally relevant conformational change of the C terminus after the transfer of reducing equivalents from NADPH to the redox sites of the enzyme.

Since 2005, when the first GLP-1 medication, exenatide, was approved, the class has evolved with more effective and longer-acting options