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It gives 8 to 18 percent for the combination, describing the range as tolerability dependent, against 5 to 15 percent for semaglutide alone and 3 to 8 percent for metformin alone

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If you are struggling with side effects from GLP-1s or are not able to reach your glycemic goals, you may want to consider speaking with a healthcare provider about a fixed-ratio combination drug like Xultophy or Soliqua and whether it could be a fit for you

Semaglutide works by binding to GLP-1 receptors in the body, which increases insulin release and decreases glucagon levels