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Beylot-Barry M, Mahe E, Rolland C, de la Breteque MA, Eychenne C, Charles J, Payen C, Machet L, Vermorel C, Foote A, Roques C, Bosson JL (2022) Evaluation of the benefit of thermal spa therapy in plaque psoriasis: the PSOTHERMES randomized clinical trial

Several pathophysiological mechanisms contribute to the onset of these complications, including IR, hyperandrogenism, chronic inflammation, and metabolic abnormalities

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434,435,436,437 The majority of phase II and III trials center around neurotransmitter receptors and A mechanisms, while tau and inflammation drugs are more prominent in phase II, often featuring repurposed compounds