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If orforglipron is approved, similar precautions are likely to apply

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Decisions were guided by the tools signaling questions, and both domain-level and overall judgments followed the standard RoB 2 algorithm, yielding categories of low risk, some concerns, or high risk

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The efficacy of IDegLira (Insulin Degludec/Liraglutide combination) in adults with type 2 diabetes inadequately controlled with a GLP-1 receptor agonist and oral therapy: DUAL III randomized clinical trial