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mirabilis will also be an important future avenue, especially given that the bladder is not sterile and most CAUTIs are polymicrobial, given its exposure to unsterile urine

demonstrated that MSU crystals could promote the maturation of IL-1 and IL-18 in THP1 cells and purified human monocytes with the presence of caspase-1 (60)

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and markers of thrombosis and endothelial cell activation including plasminogen activator inhibitor-1 (PAI-1), protein C, protein S, Von Willebrand factor (vWF), factor IX, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion protein 1 (VCAM-1) (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Ginsberg Y., Khatib N., Weiner Z., Beloosesky R