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If this happens consistently, switch to a shorter needle, use a 45-degree angle instead of 90 degrees, or choose a site with more subcutaneous tissue like the abdomen

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If you feel more tired after a dose increase this is normal, but if tiredness is beginning to interfere with your daily routine, then it might be worth reducing your dose again

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He only fully appreciated its relevance once Dupr demonstrated that GIP suppressed insulin three years later (Brown

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