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Intraperitoneal glucose tolerance test (ipGTT) Ten-week-old C57BL/6 J mice (The Jackson Laboratory, Bar Harbor, ME, USA) were administered the indicated drugs (15 nmol/kg) and maintained for 24 h, prior to testing, including a 6-h fasting period immediately before the ipGTT

Ozempic does not actively deplete B12 or alter its absorption in the gut

These pharmaceutical agents mimic the action of natural GLP-1 but are resistant to rapid degradation

Vitamin C is part of the antioxidant network glutathione recycles

Protein kinase C in enhanced vascular tone in diabetes mellitus

Time from baseline assessments to index date and time from baseline assessments to index date squared were both included in the model to control for non-linearity in effect based on time