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Data from the Phase III clinical trial showed that supplementation selenium in a concentration of 200400 g for 35 years did not lead to any adverse outcomes such as prostate cancer mortality or PSA velocity in patients with a high risk of prostate cancer [75]

Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output

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Med Clin North Am 2008