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Regeneron has signaled plans to initiate Phase 3 trials, likely in 2027, using its own in-licensed GLP-1/GIP dual agonist (olatorepatide) as the incretin backbone rather than Novo Nordisks semaglutide

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2.2 Metabolism of TMAO The metabolic pathway of TMAO is an intricate process involving the enzymatic conversion of dietary choline to TMA by specific gut microorganisms ( Figure 2 )