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2.2 Preclinical and clinical applications Resveratrol has demonstrated multifaceted antitumor potential across breast, colorectal, and hematologic malignancies through preclinical studies, though clinical translation remains challenging due to pharmacokinetic limitations and insufficient high-quality clinical validation

doi: 10.1074/jbc.271.23.13422

These modifications enhance the peptide's stability and resistance to enzymatic degradation, particularly by the enzyme DPP-IV (dipeptidyl peptidase IV), thereby slightly extending its half-life compared to Sermorelin (the unmodified GHRH 1-29)