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Common Gastrointestinal Concerns Both dual and triple agonists share a class-wide side effect profile dominated by gastrointestinal issues, primarily: Nausea Diarrhea or Constipation Vomiting These effects are dose-related and typically peak during the dose-escalation phase

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Clin Infect Dis 64:939946 Hernandez AG, Kiyaga C, Howard TA et al (2021) Operational analysis of the national sickle cell screening programme in the Republic of Uganda