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The trade-off: you don't get the metabolic benefits of pulsatile GH (lipolysis spikes, acute insulin sensitivity modulation), and the constant IGF-1 elevation creates steady negative feedback to the hypothalamic-pituitary-somatotropic axis

GIP receptor signaling increases cAMP levels in the brain, which activates PKA and EPAC [102]

London, UK: RCOG (2011)