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Gastrointestinal side effects comparison Retatrutide has a notably higher GI side effect burden at maximum doses

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This is because GH is an anabolic hormone that plays an important role in muscle growth, and CJC-1295 has a proven ability to increase levels of GH in test subjects

Interestingly, this residue is conserved in Class B1 GPCRs, such as glucagon, vasoactive intestinal peptide (VIP), and glucagon-like peptide-1 (GLP-1) (Liu et al., 2025)