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Licensed weight management agents in the UK include semaglutide 2.4 mg (Wegovy) and liraglutide 3.0 mg (Saxenda), administered via subcutaneous injection

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New England Journal of Medicine, 384 (11), 9891002.

Acute tryptophan depletion alters gastrointestinal and anxiety symptoms in irritable bowel syndrome

Potential Benefits of Microdosing GLP-1 RAs Reduced Side Effects: Lower doses minimize gastrointestinal discomfort, which can improve patient adherence and overall treatment tolerability

20 While metformin has been used in pregnancy for decades, and offers a potentially safe pharmacological option for managing metabolic disturbances in PCOS pregnancies, its efficacy and longterm safety have been questioned