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The structured dose-escalation protocol used in trials was designed to minimise gastrointestinal discomfort

GLP-1 receptor agonists and colorectal cancer risk in drug-naive patients with type 2 diabetes, with and without overweight/obesity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 200.Housden L., Wong S.T., Dawes M

The most common side effects are gastrointestinal

Weight regain of 15+ lbs from lowest post-surgical weight Plateau before reaching goal weight despite adherence Persistent hunger that interferes with maintenance At least 12-18 months post-surgery Willing to commit to monitoring and follow-up No contraindications to GLP-1 class medications Less Ideal Candidates Patients within their first year post-surgery generally should not start Retatrutide