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N 5 -Formiminotetrahydrofolate Synthesis The production of N 5 -formimino-THF (5-formimino-THF) occurs during the catabolism of histidine and is catalyzed by the transferase activity of the bifunctional enzyme, formimidoyltransferase cyclodeaminase

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Later, this PLC isoform was cloned from human cells, where it has been recognized as a Ras-activated isoform that works in association with the RA domain

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