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Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-B signaling pathway via the microRNA-410-3p
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Systemic administration of therapeutics also results in off-target effects, as only a small fraction of the administered dose crosses the BBB, with the remainder accumulating and affecting peripheral tissues 71,72
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