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The FLOW trial achieved its primary endpoint with Ozempic 1mg, demonstrating a statistically significant and superior 24% relative risk reduction of kidney disease worsening, kidney failure (end-stage kidney disease), and death due to cardiovascular disease (4.9% absolute risk reduction at three years) compared to placebo, when added to standard of care
this is not just a better drug, but rather a shift in how metabolic disease is being engineered
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NF-kappaB p65 subunit mediates lipopolysaccharide-induced Na(+)/I(-) symporter gene expression by involving functional interaction with the paired domain transcription factor Pax8
