Furthermore, elevated levels of neuromedin N, fructose-6-phosphate, and estrone glucuronide in MMA also suggest that mitochondrial dysfunction can disrupt neuroendocrine, glycolysis, and steroid metabolism [59, 60], supporting the systemic nature of this disorder
Conclusion Many studies have found that oxidative stress not only promotes the ageing and injury of chondrocytes but also drives the development of synovitis in the pathogenesis of KOA
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Malacarne D, Handakas E, Robinson O, Pineda E, Saez M, Chatzi L, Fecht D