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Levels are kept in physiologic range through dose adjustment

Combining GLP-1 receptor agonists (GLP-1 RAs) with Metformin has shown promising results for women with PCOS, especially in tackling weight management and improving both metabolic and reproductive health

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Collectively, these findings suggest that L-carnitine promotes -oxidation, reduces hepatic lipid accumulation, and exerts antioxidant effects, potentially through the AMPK-SIRT1-PPAR-PGC1-CPT1 signaling network

Similarly, Sirt4 regulates lipid metabolism and metabolic flux through its influence on malonyl CoA decarboxylase and pyruvate dehydrogenase, while also modulating mitochondrial signaling via AMPK-PGC1 and PPAR pathways