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49 Moreover, administration of high doses of IL-1 fails to exacerbate APAP-induced liver injury, further suggesting a limited role of IL-1 signaling in the pathogenesis of APAP hepatotoxicity

Jacquot JP

Consistently, Ms4a15 knockout MF cells show a decrease in the same ether species and MUFA-GPs, however, these lipids were mostly unaffected in knockdown Calu-1 and HT-1080, in agreement with unchanged viability for these cell lines (Supplementary Fig

Oeltzschner G, Wijtenburg SA, Mikkelsen M, Edden RAE, Barker PB, Joo JH, et al

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Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes