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The successful turning point for this dual therapy seems to be the substitution of conventional PPIs with a novel type of PPI, the potassium-competitive acid blocker, vonoprazan, that has a strong and durable inhibitory effect on acid secretion and generates a neutral environment in the stomach, suitable for H
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GHK-Cu adds a matrix remodeling and regenerative signaling dimension that complements the direct tissue repair activities of BPC-157 and TB-500
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