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GLP-1 group of drugs has been in use for more than 10 years for weight loss

They are multi-system agents targeting seven of the eight known contributors to insulin resistance simultaneously

- As of 2026, compounded GLP-1s remain in a shifting regulatory state

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In both my clinical experience and evidence in published studies, it is clear that many people discontinue GLP-1 treatment because of side effects, said Noom Chief Medical Officer Dr