Furthermore, in 3-month-old transgenic 5xFAD mice, liraglutide reduced astrocyte activation and A deposition while increasing levels of insulin-degrading enzyme (IDE) [52]
Researchers are already testing triple-agonist drugs, such as retatrutide, which target GLP-1, GIP and glucagon receptors
Does Retatrutide burn belly fat
Dehestani B, Stratford NRS, le Roux CW
Clinical trials show average weight loss of 15 to 17 percent of body weight over 68 weeks
This triple agonism strategy builds upon the remarkable clinical success of dual GLP-1/GIP agonists like tirzepatide, which have shown unprecedented weight loss efficacy, by adding a third mechanism - glucagon receptor activation - to further enhance metabolic benefits, particularly energy expenditure and hepatic fat oxidation