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In a Staphylococcus aureus -induced mastitis model, intake of high-dose inulin was shown to inhibit HDAC3 by promoting butyrate production in mice, thereby activating the macrophage-mediated antimicrobial defense program ( - monocytes, and enhanced alternative macrophage activation, thereby inhibiting CXCL1 production, neutrophil recruitment, and the immune response during infection (108)

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