Lyophilized retatrutide can tolerate ambient temperature (up to 25C) for 2448 hours without significant degradation, but extended exposure causes 1525% monthly potency loss
By removing both semaglutide and tirzepatide (the actives in Wegovy and Zepbound, respectively) from its drug shortage list, the agency is cutting off the primary legal route that allows compounders to make copycats
Phase 2 body composition data from the Lancet Diabetes and Endocrinology substudy showed retatrutide achieving fat mass reductions of 15.2% at the 4mg dose, 26.1% at 8mg, and 23.2% at 12mg, while the proportion of lean mass loss relative to total weight loss remained comparable to other GLP-1 compounds
Food and Drug Administration have reported increased numbers of Emergency room visits and hospitalizations related to complications caused by these medications
1) Cancer and Thyroid Concerns Semaglutide is also not recommended for people with a family or medical history of medullary thyroid carcinoma (MTC), medullary thyroid cancer, and thyroid tumors or those with Multiple Endocrine Neoplasia syndrome type 2
single-receptor agonists