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Viscous (oil-based or crystalline) medications, such as certain antibiotics or hormones, require a 22-G or 23-G needle to prevent the syringe from clogging and to allow for smooth plunger operation

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Biochem J 262:881885 Bailey CJ, Mynett KJ, Page T (1994) Importance of the intestine as a site of metformin-stimulated glucose utilization

That's the starting bid for insurance coverage and what the copay is usually based on