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The 12 mg group achieved 24.2% weight loss at 48 weeks in Phase 2, and 28.7% at 68 weeks in the Phase 3 TRIUMPH-4 trial

Then, a May 2025 NEJM head-to-head study comparing tirzepatide with semaglutide confirmed that Mounjaro led to greater mean weight loss and waist reduction over 72 weeks

What the Research Says Clinical Trials on Semaglutide When looking at the clinical trials that led to FDA approval, semaglutide stands out for its powerful weight-loss and blood sugarregulating effects

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