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Recent emerging studies, such as the investigation into Aconitum pendulum polysaccharides (APPs), have explicitly recognized this limitation, stating that while microbial shifts were observed, causal verification via FMT remains essential for future validation ( in vivo blocking), thus forming the shortest closed-loop evidence chain of key molecules-key receptors/pathways-key phenotypes

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Bachetti, C

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PMCID: PMC5556182

Marini F, Hall B, Dembinski J, Studeny M, Sasser AK, Andreeff M