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In behavioral assays with males, approximately 90% of males responded to the natural female cue as well as its synthetic analogue uridine-di-phosphate (Hardege et al., 2011), while in all randomly collected males from the field, response rates never significantly exceeded 50% of the males tested (Hardege et al., 2002)

The newer, much larger sibling-comparison results suggest those earlier signals may largely reflect background family factors rather than a direct drug effect

other regenerative compounds comparison GHK-Cu is unique in combining topical accessibility with deep gene-level regulatory activity

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The work supports the broader HGF/c-Met mechanism beyond the hippocampal cognitive context, and the zebrafish protection model has been further studied in subsequent work in mammalian systems

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