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We identified 970 potential target genes of glutathione and 2381 differentially expressed genes of heart failure, with 80 genes overlapping in both groups

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when they are depleted, we may experience the symptoms of oxidative stress

That question requires trials, and trials take years

After excluding exogenous compounds, including dietary components, environmental contaminants, and drug-related metabolites, 267 features were classified as human endogenous metabolites (Table S1)