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Titration to higher doses (0.5 mg, 1.0 mg, 2.4 mg) over 1620 weeks generally produces clinically meaningful weight loss patterns

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This 2-month discontinuation recommendation reflects semaglutide's pharmacokinetics rather than evidence of direct fertility impairment

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Oral semaglutide 25mg produced average weight loss of 13.6% to 16.6% over 64 weeks, while Wegovy 2.4mg injections produced around 14.9% to 15.2% in major trials

21,23 Managing other preexisting GI conditions, such as gastroesophageal reflux disease or constipation, before initiating GLP-1 RAs can reduce the likelihood of severe GI AEs and improve overall tolerability