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Evidence regarding butyrates effect on sterol regulatory element-binding protein 2 (SREBP2) signaling is somewhat divergent, likely reflecting model- and context-dependent regulation

In the STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) for obesity, participants with baseline binge eating behaviors showed improvements in eating-related measures alongside weight loss, as assessed by questionnaires such as the Control of Eating Questionnaire

Between 5 to 30% of these cases result in acute kidney injury (AKI)

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