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These beneficial effects of GLP-1RA on MACE are independent of many variable including the presence of established CV disease at baseline, the structural basis of GLP-1RA (exendin-4 based agonists vs

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Fish Oil Supplementation Any diet that helps you lose significant fat will lower inflammation Fat tissue (especially visceral fat) pumps out inflammatory chemicals The diet Andrew described (meat, fish, eggs, hard cheese, fruit, vegetables) works because it lacks hyperpalatability Hyper-palatable foods = refined carbs + fat + salt/sugar = foods you cant stop eating Think cookies, ice cream, chips engineered to be irresistible The inflammation issue is probably more about excess body fat than specific foods Alan takes fish oil and thinks the anti-inflammatory benefits outweigh any risks If you dont eat fatty fish regularly, fish oil supplementation is probably a no-brainer Omega-3s have huge literature supporting anti-inflammatory effects (we use Thorne, try it out) 01:16:52 Added Dietary Sugars, Sugar Cravings, Tool: Protein Intake Try to limit added sugars to 10% of total calories (40-50g on a 2000-calorie diet) Alan has a sweet tooth and eats honey/maple syrup He puts a tablespoon of maple syrup in his Vietnamese-style coffee Protein powder is his main strategy for satisfying sweet cravings He makes protein smoothies that taste like dessert but are artificially sweetened This satisfies dessert cravings while hitting protein goals Much better than actual sugary desserts for body composition You get the sweet taste plus the benefits of extra protein Protein is way more satiating than sugar 01:24:03 Artificial Sweeteners (Aspartame, Sucralose, Saccharine, Stevia), Diet Soda, Weight Loss Saccharine is the one artificial sweetener that shows bad effects (gut microbiome problems, weight gain) Good news: saccharine is extinct except in old diners with pink packets Aspartame, sucralose, and stevia are all pretty much fine Youd have to consume absurd amounts to see negative effects Probably more dangerous to breathe LA air than to drink diet soda Controlled studies show that artificially sweetened beverages help with weight loss Some observational studies show concerns, but thats probably reverse causality sick people seek out diet sodas Diet sodas can actually be a great weight loss tool All artificial sweeteners are fine at normal consumption levels The amounts youd need to consume to see problems are just ridiculous 01:32:04 Caffeine, Exercise & Fat Loss Caffeine does have a modest fat-burning effect during exercise The effect is consistent, but maybe not huge enough to be a major fat loss strategy Coffee has net positive health effects on almost everything cardiovascular, mortality, etc

Interestingly, despite ASS1 we found no further spots related to the urea cycle, creatine synthesis or purine degradation that were differentially expressed between groups or diets