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The American Diabetes Associations position that metformin should remain the first-line treatment for most type 2 diabetes cases is partly driven by this cost advantage at roughly $120 per year versus over $11,000 annually for Rybelsus, metformins modest efficacy is justified for 90% of people starting type 2 diabetes treatment

Elevated homocysteine levels are linked to increased risks of cardiovascular disease, stroke, and dementia, as well as heart disease-related death

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Nat Microbiol 9(1):173184 Larabi AB, Masson HLP, Bumler AJ (2023Dec 31) Bile acids as modulators of gut microbiota composition and function

Nathan DM, Buse JB, Davidson MB, et al

Additionally, it may assist in muscle recovery post-exercise