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These shifts correlated with improvements in metabolic parameters, notably, reduced body weight and improved dyslipidemia (lowered LDL-C and total cholesterol), suggesting that modulation of the gut microbiota is one mechanism by which GLP-1 RAs confer metabolic benefits and lipid-lowering effect (26)

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GLP-1RAs, such as exendin-4 and liraglutide, can reduce neuroinflammation caused by microglia by encouraging a conversion from the pro-inflammatory M1 subtype towards the anti-inflammatory M2 phenotype

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