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Once in the bloodstream, it utilizes the large neutral amino acid (leucine-preferring) transport system to cross the BBB

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NIH/3T3 cells were stained with 0.5 M Calcein-AM and the fluorescence was detected by CLSM

doi: 10.1016/j.schres.2021.03.018 36 DiSabatoD.QuanN.GodboutJ