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With respect to diagnosis of adult GHD of classical etiology, guidelines state that adult patients with structural hypothalamic/pituitary disease, surgery or irradiation in these areas, head trauma, or evidence of other pituitary hormone deficiencies are considered appropriate for acquired GHD and that idiopathic GHD as which occurs during aging requires stringent criteria to make the diagnosis

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Insulin-like growth factor-I (IGF-1) and insulin are also lowered to conserve energy and protein [44]