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Mechanism of Action Phentermine: Stimulates the brain to suppress appetite GLP-1 injections: Mimic natural hormones that control hunger and fullness This is the biggest difference
Studies of GLP-1s show patients average weight loss ranges from 5% to 20% of their body weight
Freezing should be avoided, as extreme temperatures can adversely affect medication stability
The use of GLP-1 drugs may be associated with an increased risk of bowel obstruction due to their mechanism of slowing gastric emptying and altering gut motility
Strategies for Comfort Eating smaller, more frequent meals can reduce nausea
The SELECT trial result - 20% reduction in major cardiovascular events with weekly semaglutide 2.4mg in adults with established cardiovascular disease plus overweight/obesity - was the first time a weight-loss medication demonstrated cardiovascular outcome benefits in a major randomized controlled trial
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