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Notch receptor activation inhibits oligodendrocyte differentiation

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UA exerts a pro-oxidant effect inside cells by activating peroxynitrite-mediated lipid oxidation, stimulating pro-inflammatory biomarkers, and decreasing antioxidant nitric oxide (NO) endothelial levels [31]

The compound's triple agonist mechanism may be considered sufficiently comprehensive that additional combinations aren't prioritized in the development pipeline

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