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Seahorse assay Oxygen consumption rate was measured using a Seahorse Bioscience XF96 analyzer with an XF Cell Mito stress test kit (Agilent, 103015-100)

Klotho is strongly expressed in the kidney and the level there is related to its functional state (Wang et al., 2018

De plus, son pouvoir antioxydant permet de ralentir le vieillissement prmatur de la peau, et de retarder lapparition de taches cutanes de vieillesse

It penetrates fast to soften the skin barrier and prepare the face for better absorption of serums or creams

Mechanistically, inhibition of complex I is expected to reduce mitochondrial ubiquinol (CoQ 10 H 2 ) levels, promoting lipid peroxidation and sensitizing cells to ferroptosis 107

doi:10.1056/NEJMoa2410659