Both of these isozymes have been putatively linked to assist the oxidative protein folding process in the ER using hydrogen peroxide and GSH as substrates [1, 8]
| | Aggressive Stack | 12.515mg weekly (therapeutic dose) | 100mg daily | Weekly + daily | Maximal incretin effect + maximal NNMT inhibition | 1624 weeks | Highest theoretical synergy but also highest metabolic stress
Why is this occurring, and how can it be avoided
In rodent models, peripheral administration of exendin-4 (EX4), a GLP-1RA has been shown to reduce motivation for sucrose, as evidenced by decreased responding in progressive ratio operant-conditioning tasks (Dickson et al., 2012)
doi: 10.1007/s00127-015-1043-0 27 SpitzerRLWilliamsJBKroenkeKLinzerMdeGruyFV3rdHahnSRet al
They contribute to tissue repair and regeneration throughout the body, and are implicated in physiologic functions like skin collagen production and hair follicle growth